深圳市儿童1型糖尿病发病率调查

Investigation on incidence of childhood type 1 diabetes mellitus in Shenzhen

目的:获得深圳地区儿童1型糖尿病(T1DM)年发病率资料,为进一步研究儿童糖尿病提供依据。方法:该研究采用捕获再捕获方法(Capture Recapture Method,CRM)回顾性调查深圳市所有1999年1月1日～2006年12月31日新发病的0～14岁T1DM儿童,按2000年深圳市人口普查公布的数据和2005年1%人口抽样调查数据的平均值作为1999～2006年的平均人口数计算年龄别和性别别年发病率。结果:1999～2006年共调查深圳市0～14岁儿童T1DM39例,男19例,女20例;平均年发病率为0.7370/10万,预计年发病率为0.7559/10万(95%CI:0.7181～0.7937/10万);8年中以2004年的发病率最高(1.9654/10万);以10～14岁组年发病率最高(1.2700/10万);男女性别间T1DM发病率(男:0.7145/10万,女:0.7598/10万)差别无统计学意义(χ2=0.04,P>0.05)。结论:深圳市儿童T1DM年发病率为0.7370/10万,预计年发病率为0.7559/10万(95%CI:0.7181～0.7937/10万),10～14岁组儿童T1DM发病率较高,男女性别间T1DM年发病率差别无统计学意义,与其它国家相比深圳市0～14岁儿童T1DM年发病率处于较低水平,而与国内其它城市相比,深圳市0～14岁儿童T1DM年发病率处于中等偏高水平。

Objective： To get the data of childhood type I diabetes mellitus （TI DM） incidence in Shenzhen, provide a basis for further study of T1DM. Methods： A retrospective epidemiological study on the incidence ot flDM among children aged 0 - 14 years was conducted in Shenzhen from January 1999 to December 2006 by capture recapture method （CRM） . Results： 39 children aged 0 - 14 years with T1DM were found from 1999 to 2006, including 19 boys and 20 girls; the mean incidence was 0. 737 0/100 000 per year; projected incidence was 0. 755 9/100 000 per year （95% CI： 0. 718 1 - 0. 793 7/100 000） ; the incidence of 2004 was the highest （ 1. 965 4/ 100 000 per year） , while the incidence of children aged 10 - 14 years was the highest （ 1. 270 0/100 000 per year） ; there was no significant difference in the T1DM incidence between boys （ 0. 714 5/100 000 per year） and girls （0. 759 8/100 000 per year） （χ^2 = 0. 04, P 〉 0.05 ） . Conclusion： The incidence of T1DM is 0. 737 0/100 000 per year, projected incidence is 0. 755 9/100 000 per year, the incidence of children aged 10 -14 years is the highest, there is no significant difference in the T1DM incidence between boys and girls, compared to other countries, the incidence of T1DM in Shenzhen is low, but compared to other cities in China, the incidence is a little high.