子宫颈癌组织XIAP蛋白表达及其意义

The expression and significance of X-linked inhibitor of apoptosis protein in cervical carcinoma tissues

目的:探讨XIAP蛋白表达在子宫颈癌发生、发展过程中的作用,以及XIAP蛋白表达与子宫颈癌患者的年龄、癌细胞分化程度、病理分期和淋巴转移之间的关系。方法:通过HE染色从组织病理学确定子宫颈组织的良、恶性以及恶性组织的分级和分期,应用免疫组织化学SP法检测65例子宫颈癌组织和24例慢性子宫颈炎组织中XIAP蛋白的表达情况。结果:①慢性子宫颈炎组织XIAP蛋白表达的阳性率为37.50%,低于子宫颈癌组织中的73.85%,两者比较差异有统计学意义(P<0.01)。②子宫颈癌组织XIAP蛋白表达随分化程度降低而升高(P<0.01),有淋巴转移的患者高于无淋巴转移的患者(P<0.05);子宫颈癌组织XIAP蛋白表达与患者年龄、病理分期无关(P>0.05)。结论:XIAP蛋白在子宫颈癌组织中表达水平明显升高,提示它与子宫颈癌发生、发展有密切关系,子宫颈癌组织XIAP蛋白表达水平的差异,对子宫颈癌的病理诊断及其分级有参考价值,干扰XIAP的表达可用于子宫颈癌的治疗。

Objective ： To explore the effect of X - linked inhibitor of apoptosis protein （XIAP） on the occurrence and development of cervical carcinoma and the relationship between XIAP expression and age, cancer cell differentiation degree, pathologic staging and lymphatic metastasis. Methods： HE staining was used to determine whether the cervix tissue was benign or malignant and definite the grading and staging of the malignant tissues histopathologically. The expression level of XIAP protein in 65 cases of cervical carcinoma tissue and 24 cases of chronic cervicitis tissue were detected by Immunohistochemical staining. Results ： The positive rate of XIAP protein in chronic cervicitis tissue was 37.50%, which was lower than that （73.85%） in cervical cancer tissue （P 〈 0. 01 ） ; The XIAP protein expression in cervical carcinoma tissue increased with the decline of cancer cells differentiation degree （P 〈 0. 01 ）, and the expression level of XIAP protein was higher in the patients with lymphatic metastasis than those without lymphatic metastasis （ P 〈 0. 05 ） ; there was no correlation between XIAP protein expression and age, clinical staging （ P 〉 0.05 ） . Conclusion： The up - regulation of XIAP protein cervical carcinoma tissue indicates that XIAP is related to the occurrence and development of cervical carcinoma. The difference of XIAP protein expression level in cervical carcinoma tissue can serve as a valuable reference for the pathological diagnosis and grading of cervical carcinoma. It is implied that interfering with XIAP expression could be used to treat cervical carcinoma.