平阳霉素用于婴幼儿地中海贫血部分性脾动脉栓塞术的疗效

Effect of Pingyangmycin on partial splenic artery embolization in infant thalassemia

目的:评价平阳霉素用于婴幼儿地中海贫血部分性脾动脉栓塞的疗效。方法:对临床确诊的婴幼儿地中海贫血24例,分两组,A组(12例)采用平阳霉素(PYM)+明胶海绵颗粒作为栓塞剂,B组(12例)采用PVA颗粒作栓塞剂。结果:术后随访6个月,两组病例术后2周内红细胞计数及血红蛋白含量均较术前明显提高。半年后,A组红细胞计数及血红蛋白含量均保持在较高的水平,B组红细胞计数及血红蛋白含量下降趋势明显。结论:PYM+明胶海绵颗粒作栓塞剂近中期疗效满意,远期疗效还需进一步观察。

Objective： To evaluate efficiency of Pingyangmycin on partial splenic artery embolization. Methods： 24 confirmed infant cases with thalassemia were divided into two groups with 12 cases per group. A group was treated with Pingyangmycin （PYM） and gelfoam granules as embolization agents, while B group was treated with PVA granules as embolization agents. Results： Follow-up of 6 months showed that compared with status before operation, RBC and hemoglobin level increased 2 weeks later after operation. 6 months later, RBC and hemoglobin level were higher in group A, while these indexes declined significantly in group B. Conclusion： Treatment with Pingyangmycin （PYM） and gelfoam granules as embolization agents has satisfactory effect in middle term, and long-term effect still need further observation.