抑郁症患者的痛阈及其相关因素研究

The pain threshold of depression patients and its related factors

目的探讨抑郁症患者的疼痛敏感性及其相关因素。方法对20例抑郁症无疼痛患者（抑郁症组）和30例正常人（正常对照组）用贝克抑郁量表（BDI）、贝克焦虑量表（BAI）、阿森斯失眠量表（AIS）进行测查，痛阈测试仪和视觉模拟评分法（VAS）检测被试的痛阈。结果抑郁症组BDI、BAI、AIS得分和耐痛阈强度刺激下疼痛、难受程度[分别为（30．2±8．79）分，（38．5±12．07）分，（11．7±6．11）分，（69．03±20．17）分，（64．98±25．55）分]高于正常对照组[分别为（10．83±5．4）分，（24．87±4．81）分，（4．9±3．24）分，（50．92±21．16）分，（44．33±23．28）分]，差异有显著性（1=9．668、t=5．580、t=5．123、t=3．02、t=2．95，均P〈0．01），抑郁症组痛阈和耐痛阈[分别为（0．87±0．58）mA，3．82±1．3）mA]低于对照组[分别为（2．09±1．05）mA，（4．43±0．81）mA]，差异有显著性（t=4．697，P〈0．01；t=2．053，P〈0．05）；痛阈与BDI、BAI、AIS得分均呈显著负相关（r=-0．581，r=-0．245，r=-0．253；P〈0．01或P〈0．05）。采用回归分析显示BDI、BAI得分可以预测痛阈。结论抑郁症无疼痛症状患者痛阈降低，抑郁、焦虑水平与疼痛敏感性有关。

Objective To investigate the pain sensitivity of depression patients, and the related factor of pain sensitivity. Methods 20 depression patients without pain（ depression group）and 30 health people （control group） were assessed with the Beck Depression Inventory （BDI）, Beck Anxiety Inventory （BAI）, Athens Insomnia Scale（AIS）. Pain threshold was investigated by the Pain Threshold Machine and Visual Analogue Scale （VAS）. Results The score of BDI, BAI, AIS and the pain intensity, unpleasantness in depression group [ （ 30.2 ± 8.79）, （38.5 ± 12.07 ）, （ 11.7 ± 6. 11 ）, （ 69.03 ± 20. 17 ）, （ 64.98± 25.55 ） ] was higher than those in control group [ （ 10.83 ± 5.4 ）, （ 24.87 ± 4.81 ）, （ 4.9 ± 3.24 ）, （ 50.92 ± 21.16 ）, （44.33 ± 23.28 ） ] significantly （t = 9. 668, t = 5. 580, t = 5. 123, t = 3.02 , t -= 2.95, all P 〈 0.01 ）. The pain threshold and the pain tolerance threshold [ （0.87 ± 0.58 ） mA,3.82 ± 1.3 ） mA 1 in depression group were lower than that in control group [ （ 2.09 ± 1.05 ） mA, （ 4.43 ± O. 81 ） mA ] significantly （t = 4. 697, P 〈 0.01 ; t = 2.053, P 〈 0.05 ）. In depression group, the pain thresh- old was correlated to the score of BDI, BAI, AIS negatively（r = - 0. 581, r = - 0.245, r = - 0. 253 ; P 〈 0.01 or P 〈0.05 ）. The score of BDI, BAI could predicate pain threshold. Conclusion The pain threshold is decreased in depression without pain patients, and the depression, anxiety level relate to pain sensitivity.