细胞因子IL-1、IL-6和IL-8水平与胃窦癌恶病质关系

ASSOCIATION OF CYTOKINE IL-1,IL-6 AND IL-8 LEVELS WITH CACHEXIA IN PATIENTS WITH ANTRAL GASTRIC CANCER

目的探讨胃窦癌病人血清细胞因子白细胞介素(IL)-1、IL-6和IL-8的水平与恶病质发生的关系。方法125例胃窦癌病人分为恶病质组与非恶病质组,将近6个月体质量下降>10%者定义为恶病质病人。通过放射免疫学方法对胃窦癌病人及健康对照组进行血清IL-1、IL-6和IL-8含量的检测。结果胃窦癌病人血清中3种细胞因子含量较对照组均显著升高(Z=-8.186～-4.665,P<0.05),胃窦癌恶病质病人血清IL-6和IL-8含量较非恶病质病人显著升高(Z=-5.018、-3.134,P<0.05)。多因素Logistic回归分析显示,IL-6(OR=1.048,95%CI:1.021～1.075)和IL-8(OR=3.150,95%CI:0.988～10.037)为恶病质发生的高风险性因素。结论血清IL-6和IL-8水平与胃窦癌病人恶病质的发生具有相关性。

Objective To study the association of serum levels of cytokine interleukin （IL） -1, IL-6 and IL-8 with cachexia in patients with antral gastric cancer. Methods This study consisted of 125 patients with gastric cancer who were divided in to two groups： cachectic and non-cachectic. Those with weight loss more than 10% in six months were defined as cachexia. The serum levels of IL-1, IL -6 and IL-8 in patients and healthy controls were dected by radioimmunoassay. Results Serum levels of the three cell factors in the cancer patients were markedly higher than that in the control （Z=-8. 186 -- 4. 665 ,P〈0.05）, and that in the cachectic were significantly higher than that in the non-cachectic （Z=- 5.018,-3. 134,P〈0.05）. Multivariate logistic regression analysis showed IL-6 and IL-8 were high risk factors of cachexia. Conclusion Serum levels of IL-8 and IL -8 are correlated with cachexia in patients with antral gastric cancer.