子宫内膜样腺癌组织CD147和MMP-2表达及意义

THE EXPRESSIONS AND CLINICAL SIGNIFICANCE OF CD147 AND MMP-2 IN ENDOMETRIOID ADENOCARCINOMA

目的探讨CD147与基质金属蛋白酶-2(MMP-2)在子宫内膜样腺癌组织中的表达及其与临床病理参数的关系。方法采用免疫组化SP法检测31例正常子宫内膜、73例子宫内膜样腺癌组织中CD147与MMP-2的表达情况。结果CD147、MMP-2在子宫内膜样腺癌组织中的阳性表达率分别为76.71%、89.04%,均高于其在正常子宫内膜组织中的表达(χ2=29.734、38.176,P<0.01)。子宫内膜样腺癌CD147、MMP-2表达与手术病理分期、肌层浸润深度、淋巴结转移有关(χ2=4.002～6.627,P<0.05;P=0.047、0.040)。子宫内膜样腺癌组织中CD147与MMP-2的表达一致率为61.64%,两者表达呈正相关(r=0.752,P<0.01)。结论子宫内膜样腺癌组织中CD147、MMP-2的高表达可能作为子宫内膜样腺癌生物学行为的客观指标。

Objective To investigate the expressions of MMP-2 and CD147 in endometrioid adenocarcinoma （EA）,and their relationship with clinicopathologic parameters. Methods The expressions of CD147 and MMP-2 were detected in normal endometrium and EA tissues in 31 and 73 cases, respectively, by using immunohistochemical technique. Results The positive expressions of CD147 and MMP-2 in EA were 76.71G and 89.04%, respectively, which were significantly higher than those in normal endometrium tissue （x^2=29. 734,38. 176; P〈0.01）, these two expressions were associated with pathologic staging, depth of muscular invasion and lymphatic metastasis （x^2=4.002-6.627,P〈0.05; P=0.047,0.040）. The concordance rate of expressions of CD147 and MMP-2 in EA was 61.64%, a positive correlation of expressions existed between the two groups （r=0. 752, P〈0.01）. Conclusion The high expressions of CD147 and MMP 2 in EA may be used as an objective marker of biological behavior of this maliglancy.