药物性肝损伤病人126例临床分析

DRUG-INDUCED HEPATIC INJURY:A CLINICAL ANALYSIS OF 126 CASES

目的分析126例药物性肝损伤病人的病因和临床特点,以加深对药物性肝损伤的认识。方法对本院126例药物性肝损伤病人的临床资料进行回顾性分析。根据服药史、临床表现、肝功能、血清标志物及停药后的治疗效果综合判断。结果引起肝损伤的药物多见于中草药,特别是治疗皮肤病、风湿性骨关节病、肾炎等疾病的中草药(28.57%),以及抗结核药物(26.98%)、抗甲状腺药物(10.32%)和抗感染药物(10.32%)等。大多数药物性肝损伤出现于服药后1～2个月。结论影响药物性肝损伤的因素有药物种类、用药时间、联合用药等。

Objective To deepen the understanding of drug-induced liver disease by analyzing the etiology and clinical features in 126 patients with the disease. Methods A retrospective study was done in 126 patients with drug-induced disease. The analysis was based on drug taking history, clinical manifestations, liver function, serum markers and response after drug withdraw al. Results The liver-damaging drugs mostly seen in Chinese herbal medicine, especially that for the treatment of skin disease, rheumaticosteoarthrosis, and nephritis （28.57%）, antituberculosis drugs （26. 98%）, anti thyroid drug （10. 32%）, as well as anti-infective （10.32 %）, and so on. Majority of drug induced hepatitis occurred one to two months after medication. Conclusion The factors influencing drug-induced hepatitis are associated with drug category, time of medication and combined medication.