钾离子在兔腹部开放伤合并海水浸泡时对心率、心律和血压的影响

Effects of Potassium on Heart Rate,Rhythm of the Heart and Blood Pressure with Rabbits in Seawater Immersion Following Open Abdominal Injury

目的观察钾离子在腹部开放伤合并海水浸泡时对兔心率、心律、血压、血钾及生存期的影响。方法将动物随机分为腹部开放伤+海水持续灌流组(N组,10只)和腹部开放伤+低钾海水持续灌流组(L组,10只),应用腹部开放伤合并海水灌流的动物模型,观察含不同浓度钾海水对动物心率、心律、血压、血钾及生存期的影响。结果①低钾海水灌注组生存时间明显长于普通海水组(P<0.05);②海水持续灌流组血钾浓度明显升高(P<0.05);③海水持续灌流组血压明显降低,心率略有减慢,没有发现有意义的心律失常。结论钾离子在腹部开放性损伤合并海水灌流中对动物的心率、血压和生存期有明显影响,可能与其心肌抑制作用有关;未出现严重心律失常,发生机制不明。

Objective To investigate the effects of potassium on heart rate,rhythm of the heart, blood pressure, concentration of serum potassium and survival time with rabbits in seawater immersion following open abdominal injury. Methods Twenty healthy rabbits were randomly divided into two groups. A rabbit model of open abdominal wound was established. Normal-potassium-concentration seawater immersion group （N group, n= 10） and low-potassium-concentration seawater immersion group（L group, n=10） were subjected to different sustained seawater perfusions after open abdominal wound. Changes of heart rate,rhythm of the heart, blood pressure, concentration of serum potassium and survival time were observed. Results ①The average survival time of L group was significantly longer than that of N group（P〈0.05）. ②Concentration of serum potassium of N group was significantly higher than that of L group（P〈0.05）. ③Blood pressure of N group was significantly lower than that of L group. No significant arrhythmia was found. Conclusion Potassium significantly affects heart rate, blood pressure and survival time with rabbits in seawater immersion following open abdominal injury. These phenomemon may be linked to its inhibition on cardiac myocyte. The reason for the absence of severe arrhythmia remains unclear.