聚乙二醇对羟基磷灰石纳米晶粒形成的影响

Effects of polyethylene glycol on formation of hydroxyapatite nano-crystals

用聚乙二醇(PEG)对羟基磷灰石(HA)进行不同的表面改性处理,考察PEG对HA纳米晶粒形成的影响。以PEG作为反应物媒介对HA进行物理修饰和在HA合成煮沸后加入PEG进行表面修饰。结果表明:以PEG作反应媒介合成HA得到的浆料在静置12 h后能够保持51%的高度,HA颗粒通过一条或多条链串在一起;合成煮沸后加入PEG改性处理得到的HA浆料保持45%的高度,相对于无改性的HA,晶粒明显地呈现针状,但长度相等。改性后均使PEG吸附在HA表面,低温烧结后晶粒结构趋同。PEG作反应媒介,能够阻止HA晶粒的生长,减少晶粒的大小。而合成煮沸后PEG的加入,不影响HA晶粒的生长发育。

Polyethylene glycol （PEG） was coated on the surface of nano-hydroxyapatite （HA） particles by the modification routes to investigate the effect of PEG on the formation of HA nano-crystals. PEG as a reactive medium was selected to physically modify HA particle surface, and PEG was added to HA slurry synthesized by chemical precipitation, respectively. The results of HA slurry sedimentation show that 51% suspension height of HA slurry obtained by the PEG-medium route can be kept for 12 h, and HA particles are linked together by one or several PEG chains. The height of HA slurry is only 45 % by PEG addition after synthesis and boiling, and the morphology of HA particles exhibits acieular shape and the same size as that without coating HA. The modification makes PEG appear on the surface of HA crystals. The crystallization of HA particles is not evidently different by two methods. PEG as a medium reagent can inhibit the growth of HA crystals in some directions and to a certain extent, and reduce the size of HA crystals, however, HA crystals in the second route are not influenced by the modifier.