迟发性运动障碍患者超氧化物歧化酶、ATP酶活性改变

The activation of SOD and ATP in schizophrenic patients with tardive dyskinesia

目的探讨抗精神病药所致迟发性运动障碍(TD)患者体内自由基代谢状况与TD的关系。方法测定36例TD、36例非TD慢性精神分裂症患者及40名正常人血浆超氧化物歧化酶(SOD)、红细胞ATP酶及丙二醛(MDA)浓度,并进行三组间方差分析;生化指标与异常不自主运动量表(AIMS)总分间的相关性采用直线相关分析。结果对照组血清SOD活性、ATP酶活性均高于TD组及非TD组,对照组MDA浓度低于TD组及非TD组,差异均有统计学意义(均P<0.05),TD患者血清SOD活性、ATP酶活性、MDA浓度与非TD组间的差异均有统计学意义(均P<0.05)。AIMS总分与SOD、ATP酶、MDA均有显著相关(r=-0.225,r=0.225,均P<0.05)。结论TD患者的血清抗氧化酶、ATP酶活性、脂质过氧化物异常,自由基代谢障碍可能与TD关系密切。

Objective To investigate the relationship of free radical metabolism with Tardive Dyskinesia （TD） in patients with TD. Methods The activities of SOD,ATP and the level of MDA in normal volunteers（n=40）, schizophrenic patients with TD（n= 36） and schizophrenic patients without TD （non-TD, n = 36） were assayed. Results The activities of SOD and ATP in normal controls were significantly higher than those in patients with TD and patients without TD,while the level of MDA in normal controls was significantly lower than that in other groups. There were significant diferences between TD group and non-TD group in the activiaies of SOD and ATP,as same as the level of MDA. Total score of AIMS was significantly correlated with the activities of SOD and ATP,level of MDA. Conclusion The activities of SOD and ATP and the level of MDA in the patients with TD would be abnormal. Abnormality of free radical metabolism may be involved in the development of TD.