脑动脉硬化症中医证候群筛选的研究

Study on syndrome screening of TCM about cerebral asteriosclersis

目的:研究脑动脉硬化症的中医证候分布特点,确定其证候诊断标准。方法:通过收集脑动脉硬化症患者四诊信息,采用系统聚类分析,筛选、归纳出脑动脉硬化症的中医证候群,从而确定脑动脉硬化症的证候诊断标准。结果:脑动脉硬化症的中医证型分布主要为4型:气虚血瘀、痰瘀互结、肝肾亏虚、阴虚阳亢。证候分布研究结果提示,在重度脑动脉硬化(弥漫性脑动脉硬化)患者中以肝肾亏虚证型为主,而在轻度脑动脉硬化中以气虚血瘀型为主。结论:对所筛选证型标准与临床专家所作出的诊断结果进行一致性比较,Kappa值大于0.75,说明本标准与专家诊断结果基本一致,可应用于临床。

Objective： To study the characteristics of syndrome distribution of TCM about cerebral arteriosclerosis（CAS）, and decide the diagnostic criteria of syndrome. Methods： The information from the TCM four diagnostic methods of patients suffering CAS was first collected, and the syndrome of TCM was screened and summarized through method of hierarchical cluster. Then the diagnostic criteria about CAS on TCM was determined. Results： The syndrome distributions about CAS on TCM were divided into four groups： deficiency of qi and blood stasis, phlegm turbidity and stagnated blood, deficiency of the liver and kidney, deficiency of yin and exuberance of yang. The results of syndrome distribution suggested that deficiency of the liver and kidney was dominant in patients with severe CAS （diffuse CAS）, and deficiency of qi and blood stasis was dominant in patients with mild CAS. Conclusion： The diagnostic criteria about CAS on TCM is compared with the diagnostic agent made by clinical experts, and the Kappa is larger than 0.75, it demonstrates that the diagnostic criteria about CAS on TCM in our study is consistent with the result made by experts, and can be used in clinic.