尖锐湿疣组织中MMP-9的表达及意义

Expression and significance of MMP-9 in condyloma acuminatum tissues

目的:研究尖锐湿疣组织中MMP-9的表达及与CD105标染的疣体内微血管密度(MVD)和瘤体生物学行为的相关性。方法:运用免疫组化SP法检测MMP-9在35例尖锐湿疣组织、15例正常包皮组织中的表达及CD105标染的新生血管的密度,分析MMP-9在尖锐湿疣组织中的表达情况,进一步分析其表达与MVD值、临床病理特征及复发的关系。结果:MMP-9在尖锐湿疣组的表达水平明显高于正常包皮组(P<0.01),尖锐湿疣组的MVD值高于正常包皮组(P<0.01)。Spearman相关分析提示MMP-9表达水平与MVD值呈正相关。结论:MMP-9过表达可能与尖锐湿疣疣体的形成和频繁复发有关,MMP-9蛋白过度表达在尖锐湿疣疣体的血管形成中具有重要的临床意义。

Objective： To study the expression of MMP-9 in condyloma aeuminatum （CA） tissues and detect the correlation between CD105 stained MVD and the biological behaviors of the disease. Methods： The expression of CD105 and MMP-9 in 35 cases of CA and 15 cases of prepuces was studied by SP immunohistochemical method. The correlation between their expression levels and clinical pathological features was also analyzed. Results： The expression of MMP-9 in CA tissues was higher compared with normal prepuces （P〈0.01）. MVD in CA group was higher than the normal prepuces （P〈0.01）. Spearman correlation analysis suggested that the expression of MMP-9 was positively correlated with MVD. Conclusion： The overexpression of MMP-9 may be related to the occurrence and frequent recurrence of CA, and the overexpression of MMP-9 plays a key role in the angiogenesis of CA.