纳洛酮联合高压氧治疗新生儿缺氧缺血性脑病临床研究

Clinical research of Naloxone joint Hyperbaric oxygen on treatment of neonatal hypoxic-ischemic encephalopathy

目的:观察纳洛酮联合高压氧治疗新生儿缺氧缺血性脑病的疗效。方法:选择新生缺氧缺血性脑病患儿98例,随机分为两组。两组均采用常规治疗,治疗组同时静脉滴注纳洛酮和使用高压氧治疗。观察两组的临床疗效和新生儿神经行为评分(NBNA)变化。结果:治疗组和对照组的总有效率分别为92.0%和70.8%,两组比较,有显著性差异(P<0.01);治疗组NBNA评分优于对照组(P<0.05)。结论:纳洛酮联合高压氧治疗新生儿缺氧缺血性脑病效果显著。

Objective： To observe the efficacy of Naloxone joint Hyperbaric oxygen on treatment of neonatal hypoxic-ischemic encephalopathy. Methods： 98 cases of neonatal hypoxic-ischemic encephalopathy were randomly divided into two groups. Both groups were treated using conventional treatment. The treatment group were intravenous injected of Naloxone and Hyperbaric oxygen at the same time. We observed the clinical treatment effect and NBNA score situation of two groups. Results： The total efficiency of the treatment group and the control group respectively were 92.0% and 70.8%, the difference was significant （P〈0.01）. The treatment group＇s NBNA score was higher than that in the control group （P〈0.05）. Conclusion： The effect of Naloxone joint hyperbaric oxygen on treatment of neonatal hypoxic-ischemic encephalopathy is remarkable.