期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

PET/CT影像技术在神经退行性疾病动物模型研究中的应用 被引量：1

Application of PET/CT on the Research of Neurodegenerative Disease Animal Models
下载PDF
导出
摘要 PET和CT影像技术是肿瘤、痴呆症、心脑血管病等的重要临床诊断技术,近年发展的小动物PET/CT成为对人类疾病动物模型,尤其是小动物模型进行比较医学研究的最新工具,能够活体无创的、动态的、定量的从分子水平观察动物的生理生化变化,进行代谢显像、受体显像、基因表达显像等。已经广泛应用于对神经退行性疾病的研究中.本文介绍了近年来一些小动物PET/CT在退行性疾病的研究中的最新应用。 PET and CT tomography are important diagnose techniques, which are widely used in clinical diagnosis of tumor, dementia, cardiovascular and cerebrovascular diseases. The PET/CT technology developed recent years is powerful tools for the comparative medicine research on human disease animal model. The advantages of this molecular imaging technology allow detecting the animal physiological and biochemical process noninvasively, dynamically and quantitatively. In this review, the using of small animal PET/CT in Neurodegenerative diseases was summarized.
作者 高凯 张连峰
机构地区 中国医学科学院北京协和医学院实验动物研究所
出处 《中国比较医学杂志》 CAS 2009年第6期66-69,共4页 Chinese Journal of Comparative Medicine
关键词 模型 动物 正电子发射计算机断层扫描/计算机X射线断层扫描 神经退行性疾病 Model, animal Positron emission computed tomography/computed tomography Neurodegcnerative disease
分类号 R817.4 [医药卫生—影像医学与核医学]
  • 相关文献

参考文献22

  • 1Schubert M, Gautam D, Surjo D, et al. Role for neuronal insulin resistance in neurodegenerative diseases [ J ]. PNAS, 2004, 101 ( 9 ) : 3100-3105.
  • 2Lockhart A. Imaging Alzheimer's disease pathology : one target, many ligands[J]. Drug Discov Today,2006, 11( 23- 24):1093- 1099.
  • 3Klunk WE, Lopresti BJ, Ikonomovie MD, et al. Binding of the positron emission tomography tracer pittsburgh compound-b reflects the amount of amyloid-beta in alzheimer's disease brain but not in transgenic mouse brain [ J ]. J Neurosci, 2005, 25 (46) : 10598 - 10606.
  • 4Toyama H,Ye D, Ichise M, et al. PET imaging of brain with the beta- amyloid probe, [ 11 C ] 6-OH- BTA- 1, in a transgenic mouse model of Alzheimer's disease[J]. Eur J Nucl Med Mol Imaging,2005,32 (5) :593 - 600
  • 5Maeda J,Ji B, Irie T, et al. Longitudinal, quantitative assessment of , and anti-amyloid treatment in a living mouse model of Alzheimer's disease enabled by positron emission tomography[ J]. J Neurosci, 2007,27 (41) : 10957 - 10968.
  • 6姚树林,郭喆,尹大一,张锦明,王瑞民,田嘉禾.11^C-PIB PET用于阿尔茨海默病大鼠模型评价研究[J].科技导报,2008,26(8):24-26. 被引量：5
  • 7Musachio JL, Flesher JE, Scheffel UA, et al. Radiosynthesis and mouse brain distribution studies of [^11C] CP-126,998:a PET ligand for in vivo study of acetylcholinesterase[J]. Nucl Med Biol,2002,29 (5) :547 - 552.
  • 8Zhang MR, Tsuchiyama A, HaradABira T, et al. Synthesis and preliminary evaluation of F18-FetP4A, a romising PET tracer for mapping acetylcholinesterase in vivo[J]. Nucl Med Biol,2002, (29) 4: 463 - 468.
  • 9Venneti S, Lopresti BJ, Wang G, et al. PK11195 labels activated microglia in Alzheimer's disease and in vivo in a mouse model using PET[J]. Neurobiol Aging,2007 - 11 - 04, [2009 - 3 - 18]. http://www. sciencedirect. com/science? -ob = ArticleURL&-udi =B6T09- 4RWJVPR - 1&-user = 3192114&-rdoc = 1&-fmt = &-orig = search&-sort = d&view = c&-acct = C000059499&-version = 1&- urlVersion = 0&-userid = 3192114&rod5 = 150e7e65b06b341bb 804386e061d164b
  • 10Zhang MR,Maeda J, Furutsuka K, et al. [^18F] FMDAA1106 and [ ^18 F] FEDAA1106 : two positron-emitter labeled ligands for peripheral benzodiazepine receptor (PBR) [J]. Bioorg Med Chem Lett ,2003,13(2) :201 - 204.

二级参考文献4

  • 1Klunk W E, Engler H, Nordberg A,et al. lmaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B [J]. Ann Neurol, 2004, 55(3): 306-319.
  • 2Hiroshi T, Ye D, Masanori Ichise,et al. PET imaging of brain with the β-amyloid probe, [^11C]6-OH-BTA-1, in a transgenic mouse model of Alzheimer's disease [J]. European Journal of Nuclear Medicine and Molecular Imaging, 2005, 32(5): 593-600.
  • 3Nordberg A. PET imaging of amyloid in Alzheimer's disease [J]. The Lancet Neurol, 2004, 3: 519-527.
  • 4王瑞民,姚树林,郭喆,张锦明,尚爱加,田嘉禾.多巴胺D2受体PET成像在制备帕金森病大鼠模型中的作用[J].科技导报,2008,26(2):24-27. 被引量：1

共引文献4

同被引文献10

引证文献1

中国比较医学杂志
2009年 第6期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部