表皮生长因子受体在鼻咽癌原发灶和颈部淋巴结转移灶间的表达差异

Expressions of epidermal growth factor receptor in primary nasopharygeal carcinoma and lymph node metastases

目的探讨表皮生长因子受体(EGFR)在鼻咽癌原发灶和颈部淋巴结转移灶之间的表达差异及其临床意义。方法应用免疫组化方法检测86例初治鼻咽癌患者的鼻咽原发灶和相应颈部淋巴结转移灶EGFR的表达情况。结果EGFR在鼻咽癌原发灶和颈部淋巴结转移灶的阳性表达率分别为73.3%和60.5%(P=0.001);EGFR在原发灶和颈部淋巴结转移灶之间总的变化率为29.1%。结论临床上对于鼻咽癌,尤其是局部晚期鼻咽癌进行EGFR靶向治疗时,应考虑EGFR在原发灶和转移灶的确切状况。

Objective To investigate the expressions of epidermal growth factor receptor （EGFR） in primary nasopharygeal carcinoma （NPC） and lymph node metastases. Methods Archived samples of primary NPC and paired lymph node metastases from 86 patients were examined immuohistoehemically for the protein expression of EGFR. Results EGFR expression positivity was detected in the primary NPC and lymph node metastases at the rate of 73.3% and 60.5%, respectively, and primary and metastatic foci showed significant difference in the expression levels （P=0.001）. A discrepancy of EGFR expression between the primary and metastatic foci was found in 25 patients, with a discrepancy rate of 29.1% （25/86）. Conclusions The difference in EGFR expression between the primary and lymph node metastastic foci of NPC needs to be evaluated when performing EGFR-targeted therapies especially in advanced NPC cases.