精神分裂症患者手术治疗前后海马磁共振质子波谱成像的研究

Proton magnetic resonance spectroscopic imaging of the hippocampus in schizophrenia patients before and after surgery

目的探讨精神分裂症患者海马磁共振质子波谱(MRS)的变化特点以及立体定向手术治疗对海马磁共振质子波谱的影响。方法应用磁共振质子波谱成像技术,对20例正常人和20例精神分裂症患者在手术治疗前、后检测双侧海马NAA/Cr和CHO/Cr的比值并进行统计分析。结果患者组在手术治疗前的NAA/Cr值低于正常对照组,患者组在手术治疗前的CHO/Cr值高于正常对照组(P<0.01)。患者组行手术治疗前与手术治疗后6个月时其双侧海马的NAA/Cr和CHO/Cr比值无显著差异(P>0.05)。结论精神分裂症患者的海马可能存在神经元的损害和细胞膜的代谢异常,立体定向手术对精神分裂症患者的细胞膜代谢无显著影响。

Objective To explore the features of proton magnetic resonance spectroscopy （^1H-MRS） of the hippocampus in schizophrenia patients before and after stereotactic neurosurgery. Methods ^1H-MRS was performed to determine NAA/Cr and CHO/Cr ratioson the bilateral hippocampal regions before and after stereotactic neurosurgery in 20 schizophrenia patients, with 20 healthy individuals as the controls. Results The NAA/Cr ratio in the hippocampal regions was significantly lower and the CHO/Cr ratio significantly higher in schizophrenia patients before the surgery than in the healthy controls （P〈0.01）. The NAA/Cr and CHO/Cr ratios in the hippocampal regions underwent no significant changes in the patients after the surgeries （P〉0.05）. Conclusion Neuronal and cell membrane metabolism impairment is present in the hippocampus of schizophrenia patients, and stereotactic neurosurgery does not produce obvious adverse effects on the cell membrane metabolism in the hippocampus of the patients.