大于40岁ALT正常慢性HBV感染者肝组织纤维化分期的研究

Liver fibrosis of chronic HBV infected patients older than 40-year-old with normal ALT.

目的观察大于40岁ALT正常慢性HBV感染者的肝组织纤维化分期的情况。方法选择64例慢性HBV感染者,检测血清肝功能、HBeAg、HBVDNA、进行肝脏活检,提供肝组织纤维化分期情况。结果年龄大于40岁ALT正常慢性HBV感染者肝组织73.44%有2期及以上的纤维化。肝纤维分期与Ⅲ型前胶原、透明质酸具有相关性(P<0.05),HBVDNA、HBeAg与肝组织纤维化无相关性(P>0.05)。结论大于40岁ALT正常的HBV慢性感染者有3/4肝组织纤维分期在2期以上,应关注其抗纤维化治疗。

Objective To analyze the stages of liver fibrosis in patients aged older than 40 with normal ALT. Methods 84 patients with chronic HBV infected were investigated in this study. Liver function, HBeAg, HBVDNA, serum liver fibrosis indexes were tested. And liver biopsy was taken in all the patients and the tissues were stained with HE and Masson. Results 73.4% patients were at fibrosis stage 2 - 4. The serum fibrosis indexes correlated with the fibrosis stage of liver histology. While the levels of HBeAg and HBVDNA didnt correlate with the severity of liver fibrosis. Conclusion Liver fibrosis of patients older than 40 - year - old should be analyzed synthetically with many clinical indexes. These patients should be administered with antifibrosis therapy to prevent the progression of liver cirrhosis.