CD44v6和COX-2在子宫腺肌病中的表达及其意义

Expression and significance of CD44v6,COX-2 in adenomyosis

目的:检测黏附分子CD44v6及环氧合酶COX-2在子宫腺肌病在位、异位内膜与正常内膜中的表达,探讨CD44v6及COX-2在子宫腺肌病发病中的作用。方法:应用组织芯片观察CD44v6及COX-2在子宫腺肌病患者在位内膜、异位内膜各30例与正常子宫内膜20例中的免疫组化表达。结果:CD44v6在子宫腺肌病异位内膜中的表达高于同期在位内膜及正常子宫内膜的表达,差异有显著性(P<0.01)。COX-2在子宫腺肌病异位、在位内膜中的表达高于正常子宫内膜,差异有显著性(P<0.01)。CD44v6在分泌期的表达显著高于增生期(P<0.05)。COX-2在分泌期、增殖期表达的差异无显著性(P>0.05)。结论:CD44v6、COX-2在子宫腺肌病患者子宫内膜表达增强,可能与子宫腺肌病的发生发展有关。

Objective： To detect CD44v6 and COX-2 expression in endometriotic and eutopic endometrium in women with adenomyosis and normal endometriumand explore investigate the role of them in the pathogenesis of adenomyosis. Methods： Expression of CD44v6 and COX-2 in 30 cases of endometriotic and eutopic endometrium of adenomyosis and 20 cases of normal endometrium with the application of tissue microarray were detected. Results： Expression of CD44v6 in endometriotic was higher than that in eutopic and normal endometrium （P〈0.01）. The COX-2 expression in endometriotic or eutopic endometrium with adenomyosis was significantly higher than that in normal endometrium（P 〈0.01）. The expression of CD44v6 in secretory phase was significantly higher than in proliferative phase in normal endometrium and adenomyosis（P〈0.05）. No significant changes of COX-2 expression were found throughout the menstrual cycle in adenomyosis （P〉0.05）. Conclusion： The overexpression of CD44v6 and COX-2 may correlate with the occurrence and progression of adenomyosis.