人工感染小鹅瘟的病理形态学研究

PATHOMORPHOLOGICAL STUDY ON EXPERIMENTAL GOSLING PLAGUE

４０只雏鹅口服感染小鹅瘟病毒，在不同感染阶段剖杀雏鹅，观察各组织器官的病理变化发展规律及病理特征。接种后第１天，小肠绒毛顶部上皮首先发生坏死脱落。随着感染时间的延长，坏死、脱落向绒毛基部发展，同时，固有膜也相继发生坏死和炎性细胞浸润。由于小肠的坏死和炎性渗出逐步加剧，最后发展成为纤维素性坏死性肠炎，并在小肠的中下段形成特征性的凝固性栓子，堵满肠腔。实质器官普遍发生变性和炎性细胞浸润。肝、胰、脾、胸腺、腔上囊，发生灶性坏死。电镜观察，病毒首先损害小肠绒毛顶部上皮，心肌和肝细胞线粒体肿胀，嵴断裂，消失，基质变空，内质网扩张，核染色质溶解。

お?0 fivedayold goslings were experimentally infected with gosling plague virus by oral administrationThe infected goslings were killed at distinct postinfection stagesThe first changes were found in the small intestineThe epithelial cells at the villus tip fell off on the first day postinfectionThen necrosis and slough went down to the bases of the villusMeanwhile,the necrosis and infiltration with the inflammatory cells occurred in the membrana propriaAlong with the aggravatin of these changes,the fibrinous necrotic enteritis appeared in the small intestine ,especially,in the middlelower sections of the small intestineAs a result,a particular coagulative embolus occurred and blocked up the intestinal cavityParenchymatous organs showed degeneration and infiltration with the inflammatory cellsFacal necrosis was seen in the liver,spleen,pancreas,thymus,bursa of FabriciusObservation throught electron microscope proved that the virus first affected the epithelial cells at the villus tip of the small intestinesThe mitochondria in the cells of the heart and liver swelledThe crest became short or disappeared,and ground substance emptiedAlso,endoplasmic reticulum dilated