尿素动力学模型及尿素反弹的实验研究

The Study of Urea Kinetic Modeling and Urea Rebound

综述了尿素动力学模型的研究进展,并分析了几种模型的优缺点。建立了串联双室模型实验系统,研究了在透析间期尿素反弹的情况。该系统通过控制泵流量(F)来模拟两室室间溶质清除率(KIE);用KCl代替尿素,通过实验曲线拟合得到KIE、R2;通过与临床数据比较,获得了适合于尿素反弹系统的KIE,并研究了非灌注室浓度(A)对KIE的影响。结果显示,F=580ml/min较好地匹配了患者透析的尿素动力学特征;基于F=580ml/min进行的A对KIE影响的实验中,A与KIE没有必然联系,KIE平均值为512ml/min,标准差为10.25,且室间溶质浓度达到平衡所需的时间均为35±5min。尿素反弹的串联双室模型实验系统能够对患者透析后的尿素动力学进行较好的模拟,并具有较强的稳定性。

This paper reviews several models in urea kinetics and analyzes the relative merits of each model. In order to provide an in - depth study of urea kinetic modeling, an experimental system of in - series two - compartment urea kinetic modeling has been established to study the quality of hemodialysis and the urea rebound after the end of dialysis. The inter - compartmental solute clearance （ KIE） is simulated by a pump to control the flow rate and corresponding R2s are obtained through curve fitting. Proper KIE is chosen for the system by comparing the experimental data with clinical data, and the relationship between concentration of non -perfused compartment （A） and KIE is studied. KC1 is chosen as an analytical reagent in place of urea. The result shows that the experimental result is suitable to urea dynamics when F was 580ml/min. The mean of KIE is 512ml/min and the standard deviation is 10.25, and it is about 35 - 5min to achieve a solute concentration balance between the two compartments. A has no relationship with KIE. Experimental system can modify quite well the pest - dialysis urea dynamics, and has strong stability.