脑梗死患者外周血S-100b与NSE变化的临床意义

The Serum S-100b and NSE Changes Clinical Significance in Patient with Acute Cerebral Infarction

目的:观察急性脑梗死患者血浆S-100b蛋白、神经元特异性烯醇化酶(NSE)的浓度变化,评价S-100b与NSE在急性脑梗死中的临床价值。方法:应用ELISA法对34例急性脑梗死患者的血浆S-100b及NSE蛋白水平进行动态检测,同时应用NIHSS进行神经功能缺损评分及CT扫描,并与20例健康体检者进行比较。结果:脑梗死患者血浆NSE浓度在起病第1、3天显著高于对照组(P<0.01),第3天达峰值。脑梗死组患者血浆S-lOOb浓度明显升高,36小时达到峰值。血浆NSE与S-100b含量与梗死灶大小、神经功能缺损程度呈正相关(P<0.01),临床疗效越差血浆NSE含量越高(P<0.01)。结论:急性脑梗死患者血浆NSE与S-100b含量升高,且随病程发展不同时期升高的程度不同,其含量可反映脑梗死的病情程度;NSE与S-100b可以作为脑梗死患者脑损害程度及预后判定的客观指标。

Objective： To observe the serum S-100b andNSE changes and to evaluate the clinical significance of these two indexes in patients with acute cerebral infarction. Methods： 34 cases of acute cerebral infarctionwere selected. The concentration of S-- 100b and the level of NSE in blood plasm of these patients were detected dynamically with application of ELISA. Meanwhile, neu- ro logical deficit scores with NIHSS and CTseans were taken with these patients, and to compare with 20 healthy examinations （control group）. Results：The level of serum NSE in patients was significantly higher than control group on 1stand 3rd day （P〈0. 01） ,and it peaked on the 3rdday. The concentration of serumS-100b significantly increased and it reached to the peak on 36hours. The contents of NSEand S--100b in patients blood plasm werepositively correlated with the volume of infraction and neurological deficit scores（P〈0. 01）. The higher serum NSE levels in dicated the worse clinical curative effect（P〈0. 01）. Conclusions： Theco- ments of serum NSE and S--100b in patients with acute cerebral infarction increased, and the degree of increment differed from various stages of this disease The contents of them could reflect the severity extent of cerebral infarction. NSE and S-- 100b can be used as objective indexes for assess mere of the degree of brain damage and prognosis in cerebral infarction patients.