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免疫抑制人群中的慢性戊型肝炎病毒感染 被引量：4

Chronic infection of hepatitis E virus in the immunosuppressed
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摘要 戊型肝炎是戊型肝炎病毒(hepatitisEvirus,HEV)引起的传染病,在全球均有分布。既往认为,HEV感染呈急性自限性经过。最近,人们开始关注并认识到,在免疫抑制人群中存在着慢性HEV感染,并可进展为肝硬化,其感染可能通过输血或者动物源性传播。目前尚无慢性HEV感染的预防指南和治疗规范,但减少免疫抑制剂用量以恢复免疫抑制患者的细胞免疫可能有助于HEV的清除,HEV疫苗的接种也可能成为预防免疫抑制患者HEV感染的有效方法。 Hepatitis E is a worldwide contagious disease which is caused by hepatitis E virus （HEV）. HEV infection was believed to be a self-limited disease presenting as acute hepatitis. Recently, some concern has been arisen about the potential risk of chronic HEV infection in the immunosuppressed, occasionally leading to cirrhosis. All reported patients acquired HEV infection through blood products （blood-borne transmission） or the food chain （zoonotic food-borne transmission）. Nowadays, specific preventive and therapeutic recommendations for chronic HEV infection are lacking, However, in the immunosupressed people with a suspect of chronic HEV infection, reducing the dose of immunosuppressors for the recovery of cellular immunity may help to clear HEV, and vaccines against hepatitis E may be effective for the prevention of HEV infection.
作者 陈晶 贾继东
机构地区 首都医科大学附属北京友谊医院
出处 《传染病信息》 2009年第3期137-139,共3页 Infectious Disease Information
关键词 戊型肝炎 免疫抑制 慢性感染 疫苗 hepatitis E immunosupression chronic infection vaccine
分类号 R512.65 [医药卫生—内科学]
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参考文献27

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二级参考文献17

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共引文献19

同被引文献55

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传染病信息
2009年 第3期

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