摘要
诺如病毒是全世界范围内急性胃肠炎的主要病原。诺如病毒型别众多,GII是主要的基因组,而GII.4为最主要的基因型。组织血型抗原(histoblood group antigen,HBGA)被认为是诺如病毒的受体,不同基因簇的病毒株与不同的HBGA结合。对GII.4的进化树分析提示,诺如病毒进化迅速。对GII.4病毒样颗粒的研究表明,受体结合区域的变异导致HBGA结合方式以及抗原性的改变。诺如病毒感染后,机体产生短期的和长期的免疫力,但是机制不清。
Norovirus （NOV） infection is one of the most common causes of acute gastroenteritis worldwide. Of various genogroups and genotypes. GⅡ has been the predominant genogroup, and GⅡ.4 has emerged as the most prevalent genotype. Histoblood group antigens （HB-GAs） have been considered as the receptors of NoVs, and NoV strains from different genoelusters bind to various HBGAs. Phylogenetic analysis suggests that NoVs have evolved rapidly. Studies on virus-like particles of GⅡ.4 NoVs demonstrate that variation in and around the receptor-binding domain results in differential HBGA binding and altered antigenicity. After being infected with NoVs, bodies induce short- and long-term immune responses, but the molecular mechanisms remain unclear.
出处
《传染病信息》
2009年第3期174-178,共5页
Infectious Disease Information
