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血小板及其Toll样受体4在脓毒症中的作用研究进展 被引量：1

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摘要 研究表明，脓毒症发病过程与凝血功能异常密切相关，而血小板是联系炎症和凝血之间复杂相互作用的关键因素，危重患者血小板计数进行性下降提示预后不良。脂多糖（LPS）可与免疫细胞表面的天然免疫受体-Toll样受体4（TLR4）结合，引起一系列的免疫效应，血小板表面同样表达TLR，但对其生物学功能的研究目前尚存争议。现对血小板及其对TLR4的表达在脓毒症免疫反应中的作用研究进展作一综述。
作者 王兵 曹书华 王勇强
机构地区 天津市第一中心医院ICU
出处 《中华急诊医学杂志》 CAS CSCD 北大核心 2009年第6期668-670,共3页 Chinese Journal of Emergency Medicine
基金 天津市卫生局科技基金（06KZ72）
关键词 TOLL样受体4 血小板计数 脓毒症 凝血功能异常 免疫受体 TLR4 血小板表面 生物学功能
分类号 R459.7 [医药卫生—急诊医学]
  • 相关文献

参考文献31

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二级参考文献31

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共引文献95

同被引文献14

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二级引证文献6

中华急诊医学杂志
2009年 第6期

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