狼疮性肾炎的临床特点

Clinical features of lupus nephritis

目的:探讨系统性红斑狼疮(SLE)患者伴有肾炎的临床表现和实验室指标特点。方法:收集169例SLE患者临床资料,根据是否伴有肾炎分为肾炎组和非肾炎组,并比较两组的临床表现和实验室指标。结果:169例SLE患者中肾炎组为63例,非肾炎组为106例。与非肾炎组相比,肾炎组患者在青春期起病的比例、伴有贫血的比例、抗ds-DNA抗体阳性率显著升高;抗La/SSB抗体阳性率显著降低(P<0.05)。结论:SLE患者出现肾炎症状时抗La/SSB抗体阳性率低;患者如为青春期发病、或伴有贫血、或抗ds-DNA抗体阳性时均应高度警惕存在肾炎的可能,尽早进行肾活检。

Objective： To study the clinical features of lupus nephritis. Methods： Sera of 169 SLE patients were taken, the patients were divided into nephritis group and non- nephritis group. The clinical manifestations and the immunological parameters were analyzed. Results： Sixty-three out of the 169 SLE patients were in the nephritis group. SLE patients with nephritis showed a higher frequency of adolescent-onset, anaemia and positivity for anti-dsDNA antibody, and a lower frequency of positivity for anti-La/SSB antibody. Conclusion： SLE patients with nephritis showed a lower frequency of positivity for anti-La/SSB antibody.It is necessary to pay more attention to the SLE patients with adolescent-onset anaemia or positivity of anti-dsDNA antibody.