猪苓多糖联合乙肝疫苗治疗慢性乙型肝炎128例

Ployporus umbellatus polysaccharides combined with hepatitis B vaccine in treatiment of CHB in 128 cases

目的探讨猪苓多糖联合乙肝疫苗治疗慢性乙肝(CHB)的疗效。方法对128例慢性乙肝患者每日肌注猪苓多糖40mg,连续20d,休息10d,3个月一疗程。皮下注射乙肝疫苗30mg,每隔2周注射1次,连续6次为一疗程。同时口服维生素及一般护肝药物,重点观察对肝功能、蛋白代谢改善情况及对乙肝病毒活性指标的影响。结果猪苓多糖联合乙肝疫苗治疗CHB临床症状缓解率达87.2%,肝功能复常率达84.1%,HBsAg阴转率达11.3%,HBeAg阴转率达43.1%。结论猪苓多糖联合乙肝疫苗治疗CHB疗效肯定,是有效治疗CHB的方法之一。

Objective To observe the therapeutic efficacy of ployporus umbellatus polysaccharides combined with hepatitis B vaccine in treating chronic hepatitis B （CHB）. Methods 128 cases of CHB patients with a daily intramuscular injection of polyporus polysaccharide 40 mg,consecutive 20 days, rest 10 days, 3 moths as one course of treatment. Subcutaneous injection of hepatitis B vaccine 30 mg, once in every two weeks; six consecutive as one course of treatment. At the same time,oral vitamins and liver drug. Key observe the impact of liver function, protein metabolism, the activity indicators of hepatitis B virus. Results The clinical remission rat of CHB patients treated by polyporus umbellatus polysaccharide and hepatitis B vaccine was 87.2% ,the normalization rate of liver function was 84.1% , the negative conversion rate of HBSAg was 11.3% , the negative conversion rate of HBeAg was 43.1%. Conclusion The therapeutic efficacy of CHB patients treated by ployporus umbellatns polysaccharides and hepatitis B vaccine was sure. It is one of an effective treatment method of CHB.