观察乌司他丁治疗严重多发伤的疗效

Treatment of ulinastatin on the severe multiple injuries

目的研究乌司他丁治疗严重多发伤的临床价值。方法将64例严重多发伤患者随机分为治疗组(32例)和对照组(32例)。治疗组患者在常规治疗的基础上,自入院当天开始静脉滴注乌司他丁(UTI),对照组患者只给予常规治疗。结果两组患者平均住ICU时间、平均住院时间和多器官功能障碍综合征(MODS)发生率间差异均有统计学意义(P<0.05)。结论乌司他丁能抑制多发伤患者炎症反应,保护重要脏器功能,减少MODS的发生。

Objective To study the clinical value of ulinastatin on treating multiple injuries, Methods Sixty - four patients with severe multiple injuries were randomly divided into treatment group （ n = 32 ） and control group （ n = 32 ）. In the treatment group （ n = 32） , on the base of routine treatment, ulinastatin was administered intravenously from hospitalization, while in the control group only routine treatment was given （ n = 32）. Results There was significant difference in the time in ICU, hospitalization time, incidence of multiple organ dysfunction syndrome （MODS） between the two groups （ P 〈 0.05 ）. Conclusion Ulinastatin can suppress the inflammatory response in patients with severe multiple injuries, protect the important organ function, reduce the incidence of MODS.