冬凌草甲素抗肿瘤活性及其机制

Anti-tumor Activity and Mechanism of Oridonin

冬凌草甲素(oridonin,ORI)是一种从冬凌草中提取的贝壳杉烯二萜类活性化合物,具有消炎、抗菌、抗肿瘤等多种药理学活性。近期研究表明ORI能有效抑制肿瘤细胞增殖,并通过死亡受体介导、线粒体介导的凋亡特异性信号通路及MAPK途径、PI3K/Akt途径等凋亡非特异性信号通路诱导肿瘤细胞凋亡。也有报道发现ORI可通过自噬帮助部分细胞延缓或阻断凋亡而使细胞存活。

Oridonin （ORI） is an active natural diterpenoid product isolated from Rabdosia rubescens. It has various pharmacological activities, including anti-inflammation, antibacteria and antitumor. Recent studies have focused on the growth inhibition and apoptosis induced by ORI. The mechanisms of the latter action may involve activation of death receptor-mediated pathways, mitochondria-mediated pathways, MAPK pathways or blockade of PI3K/Akt pathway. Further, the autophagy induced by ORI is reported to facilitate tumor cells to delay or escape partially from apoptosis.