泛素连接酶在神经系统中的作用

Function of Ubiquitin-protein Ligase in Nervous System

在生物体内,蛋白酶体系统起着非常重要的作用,它调控了细胞的许多生理过程。近几年来,作为起底物特异性泛素化作用的泛素连接酶(E3连接酶)在神经系统中的研究多有报道。通过对最近神经系统中E3连接酶研究的回顾,综述了其在神经系统的发育、正常功能及神经系统疾病中的研究进展。大量的证据表明,E3连接酶在神经系统中起着极其重要的调控作用,对其深入研究必将为神经系统疾病的临床治疗提供可靠的科学依据,并且可能为揭示生命科学的奥秘提供一些思索。

The ubiquitin-proteasome pathway is involved in the degradation of proteins and it＇s regarded as an important mechanism in controlling many physiological events of cells. Recent years, great progresses on ubiquitin liagses, which act as substrate-specific regulator, have been achieved in the nervous system. In this article, we reviewed recent advances of the ubiquitin ligases in neural development, neural function and nervous system diseases. Further work in this area will hold great promise toward the understanding of life science and treatment of a wide range of neurodegenerative diseases.