血栓素B_2、6-酮-前列腺素F_1α与牙周病和冠心病关系的研究

Level of TXB_2 and 6-K-PGF_1α in the study of the relationship between periodontal disease and coronary heart disease through radioimmunoassay

目的:通过观察冠心病伴中重度牙周炎组、单纯冠心病组、单纯中重度牙周炎组以及健康对照组间血栓素B2(TXB2)和6-酮-前列腺素F1α(6-K-PGF1α)水平的差异,探讨牙周炎与心血管疾病的相互关系。方法:选取经冠脉造影明确诊断为冠心病且伴有中重度牙周炎的病人10名(CP组),单纯冠心病病人10名(C组),单纯中重度牙周炎病人10名(P组)及健康对照组(H组)10名;4组受检者的年龄、性别、体质量指数、吸烟史无统计学差异(P>0.05),高血压史4组间有统计学差异(P<0.05)。对所有受检者进行口腔检查,记录其基本资料及相关牙周指标,并抽取清晨空腹静脉血3 mL,采用放射免疫分析方法(RIA)检测其血清中TXB2和6-K-PGF1α水平,进行统计学分析。结果:CP组、C组、P组的TXB2和6-K-PGF1α水平高于H组,差异有统计学意义(P<0.05)。结论:冠心病和牙周病病人血清中TXB2和6-K-PGF1α水平升高,提示牙周炎能促进冠心病的发生发展。

AIM： To explore the relationship between periodontitis and coronary heart diseases （CHD） by comparig the levels of TXB2 and 6 - K - PGF1α in serum among four groups. METHODS ： 40 subjects were divided into 4 groups according to the diagnostic angiography and periodontal examination as group CF, group C, group P and group HP. Group HC was made up of 10 CHD patients with moderate to advanced periodontitis. 10 CHD patients without periodontitis were as group C. Group P was made up of 10 patients suffering moderate to advanced periodontitis. Group H was 10 healthy volunteers. The general information about periodontal status of all the subjects were recorded and blood samples were withdrawed. The level of TXB2 and 6 - K - PGF1α were detected by radioimmunoassay. RESULTS： The general information including age, sex, body mass index （BMI） and smoking history had no significant differences （p 〉 0.05 ） , but the hypertension history had significant differences among four groups （p 〈 0.05 ）. One way analysis of variance showed that the level of TXB2 and 6 - K - PGF1α in serum from the patients of group CP,C and P were higher than the group H （ P 〈 0.05 ）. CONCLUSION ： TXB2 and 6 - K -PGF1α may be important mediators in the initiation and progression of coronary heart disease and periodontitis and contribute correlation between CHD and periodontal diseases.