彩色多普勒血流显像结合定量分析技术评价肾血流灌注的临床研究

Clinical study on renal flow perfusion using color Doppler flow imaging combined with quantitative analysis technique

目的探讨彩色多普勒血流显像结合血流定量分析技术评价肾血流灌注的临床意义。方法采用PhilipsiU22彩色多普勒血流显像结合血流定量分析技术分别测量20例正常对照者和20例肾疾病患者的肾叶间动脉、小叶间动脉阻力指数（RI）、血管指数（VI）、血流指数（FI）、血管-血流指数（VFI），并进行比较分析。所有肾疾病患者均于彩色多普勒显像前后进行放射性核素肾动态扫描。结果20例肾疾病患者单光子发射计算机断层显像检查（SPECT）显示血流灌注减少的32只肾叶间动脉、小叶间动脉RI值明显高于正常对照组（P〈0．01），VI、FI、VFI值均明显低于正常对照组（VI，VFI，P〈0．01；FI，P〈0．05）。结论肾疾病患者的肾血流灌注显著低于正常对照组，利用彩色多普勒血流显像结合血流定量分析技术可以无创性定量评价肾血流灌注。

Objective To explore the clinical value of color Doppler flow imaging（CDFI） combined with quantitative analysis technique to evaluate renal flow perfusion. Methods Twenty patients with different renal diseases matched with healthy control subjects were examined with Philips iU22 CDFI system. CDFI system and Qlab quantitative technique were used to measure renal restrictive index（RI）, vascularization index（VI）,flow index（FI）, vascularization-flow index（VFI）. The patients all received renal single-photon emission computed tomography（SPECT） examination. Results The RI of 32 kidney with lower flow perfusion in SPECT were higher than in the contol group （ P 〈0.01）. VI,FI,VFI were lower than those in control（VI, VF1, P 〈0.01 ;FI, P 〈0.05）. Conclusions The renal blood flow perfusion of patients with renal diseases are lower than that of healthy people. It has high clinical value using CDFI combined with quantitative analysis technique to evaluate the renal perfusion of the patients with renal diseases.