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靶向超声微泡在血栓分子成像及治疗应用的研究进展 被引量：3

Progress of targeted ultrasonic microbubbles on molecular imaging of thrombus and therapeutic application
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摘要 靶向超声微泡是依靠微泡表面固有的特性或通过对微泡进行特殊处理，使其能够靶向性滞留在组织和器官血管内皮细胞上特殊的靶分子，它是实现超声分子成像的核心和关键。最新的研究显示了其在血栓形成或血栓栓塞分子成像和靶向溶栓治疗方面一些十分诱人的前景，不仅可以提高检测血栓的特异性和敏感性，而且同时可以靶向治疗血栓，
作者 胡广全 宾建平
机构地区 南方医科大学南方医院心内科
出处 《中华超声影像学杂志》 CSCD 北大核心 2009年第6期545-546,共2页 Chinese Journal of Ultrasonography
基金 国家“863”计划项目（2006AA02Z478）
关键词 超声分子成像 超声微泡 血栓栓塞 靶向性 治疗方 血管内皮细胞 血栓形成 靶向治疗
分类号 R686 [医药卫生—骨科学]
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参考文献21

  • 1Kaufmann BA, Lindner JR. Molecular imaging with targeted contrast ultrasound. Curr Opin Biotech,2007,18:11-16.
  • 2Klibanov AL. Microbubble contrast agents-Targeted ultrasound imaging and ultrasound-assisted drug-delivery applications. Invest Radiol, 2006,41:354-362.
  • 3Lowe GD. Measurement of thrombosis and its prevention. Br J Clin Pharmacol, 2002,54 : 96-100.
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  • 5Hamilton A, Huang Sir, Warnick D, et al. Left ventricular thrombus enhancement after intravenous injection of echogenie immunoliposomes-Studies in a new experimental model. Circulation, 2002,105 : 2772-2778.
  • 6区文超,修建成,谢晋国,查道刚,刘俭,郝睿,宾建平,刘伊丽.血小板受体特异性微泡造影剂靶向粘附血栓的实验研究[J].第一军医大学学报,2005,25(6):672-674. 被引量：4
  • 7Lanza GM, Wallace KD, Scott MJ, et al. A novel site-targeted ultrasonic contrast agent with broad biomedical application. Circulation, 1996,94. 3334-3340.
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二级参考文献24

  • 1Takeuchi M, Ogunyankin K, Pandian NG, et al. Enhanced visualization of intravascular and left atrial appendage thrombus with the use of a thrombus-targeting ultrasonographic contrast agent (MRX-408A1): in vivo experimental echocardiographic studies. J Am
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  • 5Unger E, McCreery TP, Sweitzer RH, et al. In vitro studies of a new thrombus-specific ultrasound contrast agent. Am J Cardiol,1998,81:58G-61G.
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共引文献6

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中华超声影像学杂志
2009年 第6期

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