1%甲氨基阿维菌素苯甲酸盐微乳剂的研制

Study on the 1% Emamectin Benzoate Micro-emulsion

[目的]研制甲氨基阿维菌素苯甲酸盐（甲维盐）微乳剂。[方法]筛选甲维盐原药的溶剂，乳化剂的种类、配比及用量，确定最佳配方和制备工艺，并进行了新剂型的药效试验。[结果]最佳配方为甲维盐：1.66％；乙醇：2.00％；吐温80：15.91％；十二烷基苯磺酸镁：9.09％；异丙醇6.00％；水：66.00％。研制的1％甲维盐微乳剂热贮后平均分解率为3.67％，冷贮后平均分解率为2.16％，透明温度范围为-4—90℃，水的硬度对制备无影响。田间药效试验表明，药后7d的防效达90％以上。[结论]研制的甲维盐微孔剂具有成本低、性能稳定、药效高等特点，具有良好的开发应用前景。

[Objective] The research aimed to study emamectin benzoate micro-emulsion. [Method] With emamectin benzoate as original medicine, the original medicine＇ s solvent,the type, dosage and percentage＇ s of the emulsion were screened out. The prescription and the feasible preparation were ensured. The characters and pharamacodynamics were studied.[Result] The prescription was composed of emameetin benzoate （1.66%）, alcohol （2.00%）, Tween 80（15.91%）, ABS-Mg（9.09%）, PMC （6.00%）, water（66.00%）. After heat treatment, the average break up percent was 2.16% ,and the cold treatment was 3.67% ,the range of clarity temperture was -4—90℃. Different rigidity water had no effect on the eonfect. The field results showed the efficacy was over 90% after 7 day. [Conclusion] The micro-emulsion had low resolution ,stabilized quality, high efficacy, and good application prospect.