头孢羟氨苄甲氧苄啶胶囊溶出度测定

Determination the Dissolution of Cefadroxil and Trimethoprim Capsules

目的:建立头孢羟氨苄甲氧苄啶胶囊溶出度测定方法。方法:以盐酸溶液(9→1000)为溶出介质,采用高效液相色谱法测定其溶出度。结果:头孢羟氨苄的浓度在38.6～192.8μg·ml^(-1)内呈良好的线性关系,r=1.000 0,平均回收率为99.1%(RSD=0.3%,n=10);;甲氧苄啶的浓度在7.8～39.0g·ml^(-1)内呈良好的线性关系,r=0.999 9,平均回收率为98.9%(RSD=0.5%,n=10)。结论:方法准确、简便,可作为制剂的溶出度测定方法。

Objective： To establish the method for the determination the dissolution for cefadroxil and trimethoprim capsules. Method： The dissolution rates were determined by HPLC, the hydrochloride acid solution （9→1000）as dissolution medium was used.Result： The linear ranges of cefadroxil and trimethoprim were 38.6 - 192.8μg·ml^-1 , r = 1. 000 0 and 7.8 - 39.0μg·ml^-1, r = 0.999 9. the average recoveries （n = 10） were 99.1% （RSD% = 0.3 % ） and 98.9% （RSD = 0.5 % ）, respectively. Conclusion： The method is accurate, and simple, it can be used for determination method of dissolution of cefadroxil and trimethoprim capsules.