摘要
目的了解急性髓细胞白血病的细胞遗传学特征及其与预后的关系。方法对41例以FAB分类标准确诊的AML初发患者的细胞遗传学资料进行回顾性分析,应用骨髓细胞短期培养法制备染色体标本,以R显带技术进行核型分析。结果共检出异常核型16例(39.0%),单纯数目异常的有2例,染色体结构异常的12例,其余2例同时有数目及染色体结构异常。本组中最常见的结构异常为t(15;17),t(8;21)。结论细胞遗传学对急性髓细胞白血病的诊断具有重要的意义,特别是与FAB分型具有特异性的t(15;17),t(8;21)染色体异常对急性白血病的诊断具有决定意义。
Objective To comprehend relationship between cytogenetic characteristics and prognosis of acute myeloid leukemia （AML）. Methods A total of 41 cases with de novo AML according to FAB criteria were studied with complete cytogenetical data. Chromosome preparations were made on bone marrow cells by using direct method and shortterm culture. Karyotypes were analyzed by R -banding in all cases. Results Totally there were 16 cases with karyotypic abnormalities, including 2 cases with numerical abnormalities, 12 cases with structural abnormalities, 2 cases with both numerical and structural abnormalities, and t（ 15;17 ） and t（ 8 ;21 ） were the most frequent structural abnormalities. Conclusions t （ 15 ; 17 ） and t （ 8 ;21 ） karyotypic abnormalities correlated with specific FAB subtypes are important indicator for diagnosis of AML.
出处
《地方病通报》
2009年第3期86-87,89,共3页
Endemic Diseases Bulletin
