耐甲氧西林金黄色葡萄球菌322株耐药分析

Analysis on Drug Resistance of 322 Methicillin-Resistant Staphylococcus Aureus

目的了解我院耐甲氧西林金黄色葡萄球菌(SAMR)的耐药现状,为临床治疗和控制该类感染提供依据。方法细菌鉴定采用phonix100全自动微生物分析仪,药敏试验采用纸片扩散法。结果我院2003年-2007年MSRA的检出率为50.4%,痰等呼吸道标本的检出率最高(60.3%)。对青霉素G、阿米卡星、复方新诺明、红霉素、庆大霉素等药物耐药严重,对万古霉素、利福霉素、呋喃妥因、左氧氟沙星和克林霉素较为敏感。结论MRSA的耐药性不断增强,临床应根据药敏结果合理用药,并采取有效的措施防止耐药菌的传播。

Objective To investigate drug resistance status of methicillin - resistant Staphy- lococcus aureus （MRSA） in our hospital in order to providing reference for clinical rational use of drug and proventing spread of MRSA. Methods The means to identifying bacterium phonix100 automatic analyzer, the sensitivity test using disk diffusion method. Results The detection rate of MRSA in all of the specimen between 2003 -2007 in our hospital was 50.4%, and the highest rate was 60.3% in spurum samples of the respiratory tract. MRSA was severely resistant to Penicillin G, amikacin, cotrimoxazole, erythromycin, gentamicin, and more sensitive to vancomycin, rifamycin, nitrofurantoin, clindamycin and levofloxacin. Conclusion Because of MRSA being determined more and more, it is very important to use antibiotics reasonably on the results of clinical rational drug and take effective measures to prevent the spread of MRSA.