畸变产物耳声发射结果与耳鸣疗效的相关性研究

A study on relationship between distortion product otoacoustic emissions and therapeutic effects in tinnitus

目的:探寻耳鸣的发病机制及有效的治疗方法。方法:对133例耳鸣患者按畸变产物耳声发射(DPOAE)异常频率与耳鸣主调是否存在对应关系分为:DPOAE对应组(73例)及非对应组(60例),均进行改善内耳微循环、营养神经的药物治疗14d,观察并评价临床疗效。结果:DPOAE对应组的治疗有效率(75.3%)高于非对应组(36.7%)(P<0.01),DPOAE对应组中的急性耳鸣亚组的治疗有效率高于亚急性和慢性耳鸣亚组(P>0.05)。结论:对于DPOAE异常频率与耳鸣的主调存在对应关系的耳鸣患者,尤其是急性耳鸣患者,改善内耳微循环的药物治疗是一种有效的治疗方法。针对不同DPOAE特点的耳鸣患者,应采取个性化的治疗方案。

Objective：To find mechanism of tinnitus and explore effective treatment for tinnitus. Method：The 133 tinnitus patients were assigned into two groups by relationship between Distortion product otoacoustic emissions and frequencies of tinnitus： relationship group（73 cases） and non relationship group（60 cases）. All 133 cases were treated with drug, such as injection of Lipo PGE1, Vitamine B1 and VitamineB12 . After 14 days of treatment the efficacy of the medicines in two groups was observed. Result：The effective rate of two groups mentioned above were 75.3% and 36.7% respectively（P〈0.01）. Furthermore, effective rate was correlative to the course of the tinnitus. Conclusion：Drug therapy can be a choice for patients who have relationship between DPOAEs and frequencies of tinnitus,especially for acute tinnitus. Personalized treatment shoud be provided.