前庭代偿过程中代谢性谷氨酸受体Ⅰ组在大鼠小脑绒球中的表达

Expression of groupⅠmGluRs in rat flocculus after unilateral labyrinthectomy

目的:阐明大鼠小脑绒球中代谢性谷氨酸受体Ⅰ组在前庭代偿过程中的作用。方法:用RT-PCR方法对单侧迷路切除术后前庭代偿过程中代谢性谷氨酸受体Ⅰ组在小脑绒球中的表达进行研究。结果:代谢性谷氨酸受体Ⅰ组在双侧绒球中均有表达,双侧的手术组和对照组比较均差异有统计学意义,而双侧之间无差异。结论:大鼠小脑绒球存在代谢性谷氨酸受体Ⅰ组,在前庭代偿过程中有变化,表明其参与前庭代偿的过程。

Objective：Studies revealed that cerebellar flocculus parafiocculus complex plays an importmant in vestibular compensation. To observe the expression change of Group I mGluRs in flocculus following left unilateral labyrintbectomy（UL）. Method：After secting left labyrinthectomy, the change of Group I mGluRs was detected by RT-PCR. Result：Group I mGluR5 was induced increase in both side flocculus after unilateral labyrinthectomy. By contrast, mGluR1 was induced decrease. However,that of the lesioned side was stronger than that of the unlesionedside. Conclusion： UL can induce change of Group I mGluRs in the flocculus. The fall in the resting discharge of the primary vestibular afferents and/or in the deafferented central vestibular neurons may cause the change of mGluRs. But the significance of the change of mGluRs in the vestibular compensation is still un-known.