KLF4在肿瘤中的研究进展

Advancement of Kriippel-like factor 4 in tumor

KLF4为锌指蛋白转录因子，含特异性转录激活区和转录抑制区，体内分布广泛，在不同的肿瘤组织中，通过抑制细胞增殖、调节细胞分化、细胞凋亡和靶基因的表达，发挥着抑制或促进肿瘤形成的双重作用。其机制可能与乙酰化修饰有关。

Krǔppel-like factor 4 （KLF4）is a subclass of the zinc-finger family of transcription factors which can be expressed in varieties of tissues. The interaction of KLF4 with the co-activator and co-suppressor is involved in the regulation of cell proliferation, cell differentiation, cell apoptosis and gene expression. Moreover,in different cellular contexts, KLF4 can function as a tumor suppressor or an oncogene via differential regulation of histone acetylation or deacetylation.