雌激素合成及代谢基因的多态性与乳腺癌易感性

Polymorphisms of estrogen synthesizing and metabolizing genes and breast cancer susceptibility

雌激素是乳腺癌的主要危险因素，推测是通过雌激素受体影响乳腺癌的发病风险。因此，与雌激素合成和代谢相关的基因多态性被认为是乳腺癌的主要危险因子。与雌激素合成基因（CYP11A1、CYP17、CYP19）和代谢基因（CYP1A1、CYP1B1、CYP1A2）相关的基因多态性在调节乳腺癌易感性中具有一定意义。

Estrogens, the major risk factors for breast cancer, are speculated to affect breast cancer risk through estrogens receptor（ ER）, thus, genetic polymorphisms of the genes involved in the estrogens biosynthesis and metabolism are expected as the main risk factors for breast cancer. Polymorphisms of the genes involved in estrogens biosynthesis（ CYP11 A1, CYP17, CYP19） and metabolism（CYP1 A1, CYP1 B1, CYP1A2） in modulating the susceptibility of breast cancer is important.