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节拍化疗与转移性乳腺癌

Metronomic chemotherapy and metastatic breast cancer
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摘要 节拍化疗是通过抑制肿瘤新生血管生成发挥抗肿瘤作用。研究表明,运用节拍化疗可明显提高转移性乳腺癌患者的生活质量,耐受性好,且有较高的效应/费用比,有望成为转移性乳腺癌的一种全新治疗模式。 Metronomic chemotherapy plays anti-tumor roles through inhibition of tumor angiogenesis.Recent studies have shown that metronomic chemotherapy may significantly improve life quality of patients with metastatic breast cancer, and has good tolerance and a high effect-cost ratio. Metronomic chemotherapy is expected to become a novel treatment model for metastatic breast cancer.
出处 《国际肿瘤学杂志》 CAS 2009年第6期446-448,共3页 Journal of International Oncology
关键词 药物疗法 血管生成抑制剂 乳腺肿瘤 Drug therapy Angiogenesis inhibitors Breast neoplasms
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参考文献21

  • 1Folkman J.Angiogenesis.Annu Rev Med,2006,57:1-18.
  • 2Drevs J,Fakler J,Eisele S,et al.Antiangiogenic potency of various chemotherapeutic drugs for metronomic chemotherapy. Anticancer Res,2004,24(3a):1759-1763.
  • 3Mancuso P,Colleoni M,Calleri A,et al.Cirulating endothelial-cell kinetics and viability predict survival in breast cancer patients receiving metronomic chemotherapy.Blood,2006,108 (2):452-459.
  • 4de Castro Junior G,Pugiisi F,de Azambuja E,et al.Angiogenesis and cancer:A cross-talk between basic science and clinical trials (the "do ut des" paradigm).Crit Rev Oncol Hematol,2006,59(Ⅰ):40-50.
  • 5Generali D,Fox SB,Brizzi MP,et al.Down-regulation of phosphatidylinesitol 3 kinase/AKT/molecular target of rapamycin metabolic pathway by primary letrozole-based therapy in human breast cancer.Clin Cancer Res,2008,14(9):2673-2680.
  • 6Bottini A,Generali D,Brizzi MP,et al.Randomized phase Ⅲ trial of letrozole and letrozole plus low-dose metronomic oral cyclophosphamide as primary systemic treatment in elderly breast cancer patients.J Clin Oncol,2006,24(22):3623-3628.
  • 7Emmenegger U,Morton C,C,Francia G,et al.Low-dose metronomic daily cyclophosphamide and weekly tirapazamine:a well-tolerated combination regimen with enhanced efficacy that exploits tumor hypoxis.Cancer Res,2006,66(3):1664-1674.
  • 8Colleoni M,Orlando L,Sanna G,et al. Metronomic low-dose oral cyclophosphamide and methotrexate plus or minus thalidomide in metastatic breast cancer:antitumor activity and biological effects.Ann Oncol,2006,17(2):232-238.
  • 9Orlando L,Cardillo A,Rocca A,et al.Prolonged clinical benefit with metronomic chemotherapy in patients with metastatic breast cancer.Anticancer Drugs,2006,17(8):961-967.
  • 10Orlando L,Cardillo A,Ghisini R,et al.Trastuzumab in combination with metronomic cyclophesphamide and methotrexate in patients with HER-2 positive metastatic breast cancer.BMC Cancer,2006,6:225.

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