副猪嗜血杆菌的分子生物学研究进展

Research progression in molecular biology of Haemophilus parasuis

副猪嗜血杆菌是存在于猪上呼吸道的正常菌,在特定条件下会引发猪种的副猪嗜血杆菌病,该病以多发性浆膜炎、关节炎及高死亡率为特征,给养猪业带来了巨大经济损失.传统的血清分型法只能将副猪嗜血杆菌分为15个血清型,但还有20%以上的分离株不能进行分型.随着分子生物学技术的不断应用,副猪嗜血杆菌的鉴定、分型、毒力相关因子的研究已取得了一些进展,综述近20年来副猪嗜血杆菌的分子生物学研究状况供相关技术人员参考.

Haemophilus parasuis is a common epiphyte of the upper respiratory tract of pigs.The bacteria can cause porcine Glasser＇s disease in special conditions characterized by fibrinous polyserositis and polyarthritis accompanied with high morbidity and mortality. The disease has resulted in enormous economic losses of the pig industry. 15 serovars of HIS have been identified via serotyping and more than 20% HIS are no-typing isolates.Research in molecular biology of H.parasuis has acquired some progress with the development of the molecular biotechnology in the latest 20 years,this article will give a review about the progress.