13例儿童垂体腺瘤的诊断和治疗

Diagnosis and Treatment of Pituitary Adenoma in Children

目的总结儿童垂体腺瘤的治疗经验,探讨儿童垂体腺瘤的诊断和治疗。方法回顾分析13例14岁以下儿童垂体腺瘤的临床表现、内分泌及影像学检查、个体化治疗情况。其中手术11例、γ刀治疗2例。结果11例手术治疗患儿,9例全切、2例次全切。随访的11例患儿,症状均得以很好控制。结论儿童垂体腺瘤以多分泌功能细胞腺瘤为主,手术中采用经颅入路或经鼻蝶入路则取决于患儿的影像学表现及诊断倾向,γ刀治疗也是一种重要的治疗手段。

Objective To sum up the experience in the individualized therapy of pituitary adenoma in children. Methods The clinical presentations, hormone assays, imaging studies and individualized therapy in 13 patients with pediatric pituitary adenomas were analyzed retrospectively. In this group of cases,eleven cases were treated with operation, two cases were treated with gamma knife. Results Tumors were completely removed in 9 cases and subtotally in 2 cases. The symptoms in the eleven cases which were longterm followed up have been well controlled. Conclusion Multi-hormone secreting type is the most common pathological type in the pediatric pituitary adenomas. Transcranial surgery is as important as transsphenoidal surgery in the pediatric pituitary adenomas. Gamma knife treatment is a considerable treatment plan.