特发性肺间质纤维化血清外周血转化生长因子-β_1、结缔组织生长因子的检测及意义

Investigation on the levels and significance of transforming growth factor-β_1 and connective tissue growth factor in serum of patients with idiopathic pulmonary interstitial fibrosis

目的研究特发性肺间质纤维化(IPF)患者血清转化生长因子-β1(TGF-β1)和结缔组织生长因子(CTGF)水平及其与肺纤维化的关系。方法用酶联免疫吸附试验(ELISA)测定IPF组(n=78)和健康对照组(n=78)的血清TGF-β1和CTGF水平,用线性相关分析分析二者之间的相关性。结果患者组外周血TGF-β1浓度和CTGF浓度明显高于正常组(P<0.05),而且二者之间存在相关性。结论TGF-β1、CTGF与IPF的发病机制有关。

Objective To investigate the levels of transforming growth factor -β1, （TGF -β1 ）and connective tis- sue growth factor（CTGF） in serum of patients with idiopathic pulmonary interstitial fibrosis and the relationship be- tween their levels and pulmonary fibrosis. Methods The levels of TGF -β1 and CTGF in serum of patients with idio- pathic pulmonary interstitial fibrosis （ n = 78 ） and （ n = 78 ） were determine by ELISA. The dependability between TGF -β1 and CTGF was analyzed by linear correlation analysis. Results The levels of TGF-β1 and CTGF in serum of pa- tients had significant difference with those of the control group. The dependability between TGF -β1 and CTGF was present. Conclusions TGF-β1 and CTGF concerned with pathogenesy of IPF.