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胰腺癌相关生物活性标志物研究

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摘要 肿瘤相关生物活性标志物主要是在肿瘤发生发展过程中出现的基因变化以及合成和分泌的异常蛋白质，并可以用于诊断和鉴别肿瘤的物质。临床中胰腺癌发生是一个复杂的多基因改变以及多种蛋白表达异常的结果，这可导致相应基因突变以及蛋白的高表达，同时部分指标可以成为胰腺癌相关生物活性标志物。
作者 裘正军 刘俊
机构地区 上海交通大学附属第一人民医院普外科
出处 《中华普通外科学文献（电子版）》 2009年第3期4-7,共4页 Chinese Archives of General Surgery(Electronic Edition)
关键词 生物活性 标志物 胰腺癌 蛋白表达异常 肿瘤相关 多基因改变 基因变化 鉴别肿瘤
分类号 R735.9 [医药卫生—肿瘤]
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参考文献5

  • 1Koji Yamaguchi,Munechika Enjoji,Manabu Nakashima,Makoto Nakamuta,Takashi Watanabe,Masao Tanaka.Novel serum tumor marker, RCASl, in pancreatic diseases[J].World Journal of Gastroenterology,2005,11(33):5199-5202. 被引量：12
  • 2Constantinos Giaginis,Demetrios Davides,Apostolos Zarros,Olga Noussia,Adamantia Zizi-Serbetzoglou,Gregorios Kouraklis,Stamatios Theocharis. Clinical Significance of Tumor-associated Antigen RCAS1 Expression in Human Pancreatic Ductal Adenocarcinoma[J] 2008,Digestive Diseases and Sciences(6):1728～1734
  • 3Noritoshi Kobayashi,Masahiko Inamori,Koji Fujita,Toshio Fujisawa,Nobutaka Fujisawa,Hirokazu Takahashi,Masato Yoneda,Yasunobu Abe,Harunobu Kawamura,Takeshi Shimamura,Hiroyuki Kirikoshi,Kensuke Kubota,Takashi Sakaguchi,Satoru Saito,Lawrence J. Saubermann,Atsushi Nakajima. Characterization of K-ras gene mutations in association with mucinous hypersecretion in intraductal papillary-mucinous neoplasms[J] 2008,Journal of Hepato - Biliary - Pancreatic Surgery(2):169～177
  • 4Elizabeth G. Grubbs MD,Zeinab Abdel-Wahab MD, PhD,Douglas S. Tyler MD, FACS,Scott K. Pruitt MD, PhD, FACS. Utilizing Quantitative Polymerase Chain Reaction to Evaluate Prostate Stem Cell Antigen as a Tumor Marker in Pancreatic Cancer[J] 2006,Annals of Surgical Oncology(12):1645～1654
  • 5Maurizio Ventrucci,Antonio Cipolla,Chiara Racchini,Riccardo Casadei,Patrizia Simoni,Lucio Gullo. Tumor M2-Pyruvate Kinase, a New Metabolic Marker for Pancreatic Cancer[J] 2004,Digestive Diseases and Sciences(7-8):1149～1155

二级参考文献17

  • 1Sonoda K, Nakashima M, Kaku T, Kamura T, Nakano H,Watanabe T. A novel tumor-associated antigen expressed in human uterine and ovarian carcinomas. Cancer 1996; 77:1501-1509.
  • 2Nakashima M, Sonoda K, Watanabe T. Inhibition of cell growth and induction of apoptotic cell death by the human tumor-associated antigen RCAS1. Nature Medicine 1999; 5:938-542.
  • 3Kaku T, Sonoda K, Kamura T, Hirakawa T, Sakai K, AmadaS, Ogawa S, Kobayashi H, Nakashima M, Watanabe T,Nakano H. The prognostic significance of tumor-associated antigen 22-1-1 expression in adenocarcinoma of the uterine cervix. Clinical Cancer Res 1999; 5:1449-1453.
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  • 5Takahashi H, Iizuka H, Nakashima M, Wada T, Asano K,Ishida-Yamamoto A, Watanabe T. RCAS1 antigen is highly expressed in extramammary Paget's disease and in advanced stage squamous cell carcinoma of the skin. J Dermatol Sci 2001; 26:140-144.
  • 6Suzuki T, Inoue S, Kawabata W, Akahira J, Moriya T,Tsuchiya F, Ogawa S, Muramatsu M, Sasano H. EBAG9/RCAS1 in human breast carcinoma: a possible factor in endocrine-immune interactions. Br J Cancer 2001; 85:1731-1737.
  • 7Tsuneizumi M, Nagai H, Harada H, Kazui T, Emi M. Ahighly polymorphic CA repeat marker at the EBAG9/RCAS1 locus on 8q23 that detected frequent multiplication in breast cancer. Ann Human Biol 2002; 29:457-460.
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  • 9Oshikiri T, Hida Y, Miyamoto M, Hashida H, Katoh K,Suzuoki M, Nakakubo Y, Hiraoka K, Shinohara T, Itoh T,Kondo S, Katoh H. RCAS1 as a tumour progression marker:an independent negative prognostic factor in gallbladder cancer. Br J Cancer 2001; 85:1922-1927.
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共引文献11

中华普通外科学文献（电子版）
2009年 第3期

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