巨噬细胞移动抑制因子在溃疡性结肠炎发病中的作用

Pathogenic role of macrophage migration inhibitory factor in ulcerative colitis

目的探讨巨噬细胞移动抑制因子(MIF)在溃疡性结肠炎发病中的意义。方法检测38例活动期溃疡性结肠炎(UC,其中轻度10例,中度20例,重度8例)、23例其他结肠炎患者和20例健康体检者血清中MIF及超敏C反应蛋白(hs-CRP)含量及肠黏膜组织中MIF的表达情况。结果UC患者的血清MIF水平高于其他结肠炎及正常对照者的血清MIF水平(P<0.05);溃疡性结肠炎重度组的MIF水平高于轻度组[(12.204±2.340)μg/Lvs(9.060±1.444)μg/L,P<0.05]。溃疡性结肠炎重度组的hs-CRP水平高于轻度组[(9.002±1.538)μg/Lvs(3.556±1.283)μg/L,P<0.05]。UC患者肠黏膜的MIF表达率为100%、染色明显增强,与其他结肠炎患者及正常对照者比较均具有显著性差异(P<0.01)。结论MIF参与溃疡性结肠炎的发病过程,可能是溃疡性结肠炎活动的指标,控制MIF的产生可能有治疗作用。

Objective To explore the pathogenic role of macrophage migration inhibitory factor（MIF） in patients with ulcerative colitis （UC）. Methods A total of 38 patients with UC at active stage,23 patients with other forms of colitis and 20 normal controls were enrolled in the study. The levels of MIF in the sera and intestine tissues were detected. Meanwhile, the levels of high sensitivity C-reactive protein（hs-CRP） in the serum were measured. Results The serum MIF levels were significantly higher in UC than in other forms of colitis and normal controls （P 〈0. 05 ）. Moreover, serum hs-CRP level in the patients with severe UC was significantly higher than that in mild UC （P 〈0. 05 ）. The expression rate of MIF in UC was 100% , and the staining was significantly increased in colonic mucosa in UC than in other forms colitis （ P 〈 0.01 ）. Conclusion These results suggest that MIF may play a role in the pathogenesis of UC, and may be used as a marker of disease activity in UC. To inhibit MIF expression may be a way to treat UC.