摘要
目的研究血小板源性生长因子(PDGF-D)在IgA肾病患者肾小球中的表达及福辛普利对PDGF-D的作用。方法32例经肾活检证实为IgA肾病的患者,服用福辛普利9个月后重复肾活检。应用酶联免疫吸附(ELISA)和免疫组化法检测PDGF-D在治疗前后肾组织、血液及尿液中的表达。同时检测治疗前后24 h尿蛋白定量、血浆白蛋白(ALB)及血尿素氮(BUN)、肌酐(Cr)水平。结果IgA肾病患者肾组织PDGF-D有较高的表达,同时患者血、尿中PDGF-D的水平也较高。经过福辛普利治疗后,PDGF-D在肾组织中的表达下降(P<0.01),同时血、尿中的浓度也减少。治疗前后24h尿蛋白定量、血浆白蛋白(ALB)及血尿素氮(BUN)、肌酐(Cr)水平没有显著的变化。结论福辛普利能显著抑制IgA肾病患者肾脏PDGF-D表达。
Objective To investigate the expression of platelet-derived growth factor-D（PDGF-D） and the effect of Fosinopril in patients with IgA nephropathy. Methods The level of PDGF-D in 32 patients with IgA nephropathy confirmed by renal biopsy was examined by Enzyme-linked immunosorbent assay（ELISA） and immunohistochemistry after the treatment with Fosinopril for 9 months. The levels of 24-hour urinary protein excretion, serum albumin （Alb）, serum blood urine nitrogen （BUN） and creatinine （Cr） were also determined. Results The high expression of PDGF-D was founded within renal tissues in patients with IgA nephropathy ,The levels of 24-hour urinary protein excretion , serum albumin（ AIb）, serum blood urine nitrogen（BUN） and creatinine （Cr） were also high and not changed after treatment. But the expression of platelet-derived growth factor-D was decreased after therapy with Fosinopril for nine moths. Conclusion Fosinopril might significantly inhibited the expression of PDGF-D in patients with IgA nephropathy.
出处
《中华全科医学》
2009年第7期675-676,共2页
Chinese Journal of General Practice
基金
广东省佛山市医学类科技公关项目(200708085)
