三联疗法治疗十二指肠溃疡的临床观察

Clinical Effect of Gatifloxacin Based Triple Therapy in Treatment of Duodenal Ulcer

目的探讨加替沙星、泮托拉唑和阿莫西林一周疗法对幽门螺杆菌(Hp)阳性十二指肠溃疡治疗效果。方法将82例Hp阳性的十二指肠溃疡患者随机分为治疗组和对照组,分别使用加替沙星联合泮托拉唑、阿莫西林和泮托拉唑联合克拉霉素、阿莫西林进行治疗。结果治疗组、对照组的Hp根除率、溃疡愈合率、不良反应相比,差异均无统计学意义(P>0.05)。结论加替沙星、阿莫西林、泮托拉唑三联疗法对治疗Hp感染的十二指肠溃疡有较好的疗效。

Objective To explore the curative effect of seven days therapy consisted of gatifloxacin, amoxicillin and panto- prazote for H. Pylori positive duodenal ulcer. Methods Eighty two cases with Hp positive duodenal ulcer were randomly divided into two groups. The treatment group（ n = 42） was treated with Gatifloxacin, amoxicillin and pantoprazole for seven days, while the control group（ n = 40） was treated with elarithromycin, pantoprazole and amoxicillin for seven days. Results The eradication rate of Hp,rate of ulcer cicatrization and adverse events were similar in both groups（P 〉 0.05）. Conclusion Gatifloxacin based triple therapy is safe and effective for H. Pylori positive duodenal ulcer.