血小板和D-二聚体联检在DIC诊断中的应用

Combined Determination of Platelet and D-Dimer for Diagnosis of DIC

目的探讨血小板数量和D-二聚体(D-D)含量在弥漫性血管内凝血(DIC)发生过程中的变化。方法胶体金法检测DIC患者及正常对照组血浆中D-D的含量,同时采集全血检测血小板数量。并对12例重型DIC患者血浆中D-D和全血血小板数量进行了为期10 d的动态监测。结果血浆中D-D的含量在DIC组显著增高,与对照组比较差异均有统计学意义(P<0.01)。血小板呈短暂上升后明显降低或与发病初期相比明显降低(P<0.01)。动态观测中,D-D变化不大,而血小板计数短暂上升后明显降低,且随着治疗过程有一定的回升。结论二者联检可以明显提高DIC的诊断效率,且血小板因出现较早且随着治疗的过程能同步变化,可作为一较理想的动态监测指标。

Objective To observe the change of plasma D-Dimer（D-D） levels and platelets counting in patients with disseminated intravascular coagulation （DIC）. Methods The D-D level was detected by colloidal gold method and platelet counting were measured in 39 cases of patients with DIC and 40 cases of normal controls. 12 patients with severe DIC were continuously monitored for 10 days. Results The level of D-D in DIC group were significantly higher than that in normal control group （P 〈 0.01 ） ;the counting of platelets were significantly lower than that in normal control group（ P 〈 0. O1 ）. The continuous monitoring showed that D-D level was stable, platelets counting decreased obviously after a fleeting rising and improved with the treatment at some extent. Conclusion The joint inspection of plasma D-Dimer and platelets counting simultaneity can improve the diagnosis of DIC. The continuous monitoring of the platelet counting can guide the treatment of DIC.