f-PSA/t-PSA在前列腺增生与前列腺癌诊断中的意义

The Significance of f-PSA/t-PSA in the Diagnosis of Prostate Tumor

目的检测前列腺增生症(BPH)和前列腺癌(PCa)患者血清中总PSA(t-PSA)和游离PSA(f-PSA)及其f-PSA/t-PSA的比值,探讨其对PCa和HBP患者的诊断价值。方法采用微粒子酶免疫法(MEIA)检测54例BPH和48例PCa患者血清中t-PSA、f-PSA及f-PSA/t-PSA的比值。结果血清总PSA在4.0～10.0 ng/ml时,BPH与PCa组的t-PSA差异无统计学意义(P>0.05),游离PSA、f-PSA/t-PSA比值差异有统计学意义(P<0.05)。结论当血清t-PSA超过4.0～10.0 ng/ml时,f-PSA/t-PSA的比值对PCa和BPH的鉴别诊断具有重要的临床价值。以f-PSA/t-PSA<0.16为界定的标准,特异性为88.39%,灵敏度为79.36%。在诊断BPH和PCa时,f-PSA/t-PSA明显优于t-PSA,是早期诊断PCa的指标。

Objective To evaluate the f-PSA/t-PSA value in diagnosis prostate tumor by integrally testing the serum t-PSA, f-PSA as well as ratio of f-PSA to t-PSA. Methods The serum t-PSA, f-PSA of 54 benign prostate hyperplasia （ BPH ） and 48 prostate cancer（PCa） were measured by particle enzyme immunoassay（EMIA） ,to find out the ratio of f-PSA/t-PSA. Results When serum t-PSA ranged from 4.0 to 10.0 ng/ml. It is difficult to differentiate PCa from BPH by t-PSA or f-PSA alone. But when using the ratio of f-PSA/t-PSA 〈 0.16 as the diagnostic criterion,its specificity and sensitivity were 88.39% and 79.36% respectively, much higher than that of t-SPA, f-PSA （ P 〈 0.01 ）. Conclusion When plasma t-PSA in higher than normal, the ratio of f-PSA/t-PSA is of great clinical value in differentiating the prostate tumor from BPH.